もの忘れが気になり始めたとき

Omega-3 fatty acids and cognitive decline: a systematic review.

• 高齢者または軽度認知障害（MCI）を有する成人

原文よりTen out of the fourteen RCTs reviewed showed positive outcome on at least one domain of cognitive function (working memory, executive function, verbal memory, short-term memory, perceptual speed, etc.)

Effect of long-term omega 3 polyunsaturated fatty acid supplementation with or without multidomain intervention on cognitive function in elderly adults with memory complaints (MAPT): a randomised, placebo-controlled trial.

• 参加者 1,525人
• 記憶の訴えがある70歳以上の非認知症高齢者

原文よりIn the modified intention-to-treat population (n=1525), there were no significant differences in 3-year cognitive decline between any of the three intervention groups and the placebo group.

Omega-3 fatty acids and cognitive function.

• 軽度認知障害、アルツハイマー型認知症のリスクが高い人や冠動脈疾患のある健康な成人

原文よりSupplementation with docosahexaenoic acid (DHA) in randomized controlled trials (RCTs) in those with mild cognitive impairment showed benefit on cognitive decline, whereas there was no benefit in Alzheimer's disease.

Bacopa monnieri reduces Tau aggregation and Tau-mediated toxicity in cells.

原文よりBacopa monnieri was observed to inhibit the Tau aggregation in vitro.

Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract.

• 参加者 518人
• 標準化されたBacopa monnieri抽出物の慢性投与を受けるヒト

原文よりMeta-analysis of 437 eligible subjects showed improved cognition by shortened Trail B test (-17.9 ms; 95% CI -24.6 to -11.2; p<0.001) and decreased choice reaction time (10.6 ms; 95% CI -12.1 to -9.2; p<0.001).

Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.

• 参加者 48人
• 認知症の臨床症状がない65歳以上の健康な高齢者 48名
• 300mg/日 12週間

原文よりBacopa participants had enhanced AVLT delayed word recall memory scores relative to placebo.

Plant-derived nootropics and human cognition: A systematic review.

原文よりBacopa monnieri improves language, learning and memory.

Effects of dual-task resistance exercise on cognition, mood, depression, functional fitness, and activities of daily living in older adults with cognitive impairment: a single-blinded, randomized controlled trial.

• 参加者 44人
• 認知機能障害を持つ高齢者 44名
• 1回40分、週3回、6週間

原文よりDual-task resistance exercise is more effective than resistance exercise in improving cognitive function in older adults with cognitive impairment.

Effects of Resistance Exercise Training on Cognitive Function and Physical Performance in Cognitive Frailty: A Randomized Controlled Trial.

• 参加者 45人
• 認知フレイルを有する地域在住の高齢者 45名

原文よりStatistical analysis showed that exercise improved performance significantly in the tests for cognitive function (processing speed and executive function, both p < 0.05), physical function (SPPB, TUG, gait speed, both p < 0.05), and muscle strength (grip strength, knee extension strength, both p < 0.05).

Cognitive Effects of Aerobic Exercise in Alzheimer's Disease: A Pilot Randomized Controlled Trial.

• 参加者 96人
• アルツハイマー型認知症の高齢者 96名
• 週3回、20-50分間の有酸素運動（サイクリング）を6ヶ月間

原文よりAerobic exercise did not show superior cognitive effects to stretching in our pilot trial, possibly due to the lack of power.

Effects of exercise interventions on cognitive functions in healthy populations: A systematic review and meta-analysis.

• 健康な子供、成人、および高齢者

原文よりExercise benefitted overall cognition and all subcognitive domains. Aerobic and resistance exercise showed the greatest benefits on global cognition and executive function respectively, whereas mind-body exercise benefitted memory.

Physical exercise, neuroplasticity, spatial learning and memory.

• 成人および高齢者、動物モデル

原文よりIn humans, several studies have shown the beneficial effects of aerobic and resistance exercises in adult and geriatric populations.